Known since antiquity for its therapeutic virtues, cannabis is used medically in various European countries as well as in the United States where some of its derivatives can be dispensed by prescription. Anti-pain, antispasmodic, anti-nausea …
Cannabis would find its place in the management of several diseases, some particularly serious ones such as AIDS or multiple sclerosis.
If the indices of a real benefit accumulate, large-scale studies are still lacking to definitively determine the therapeutic potential of hemp.
One particular problem is the anti-drug administration.
When talking about cannabis, we often talk about seal, drugs and banning … Yet this substance also has medicinal properties for some patients, properties that are increasingly recognized around the world but not everywhere.
The point on this question: cannabis, is it only a drug?
Cannabis, a long-known medicine
These virtues have been known since antiquity when cannabis was used medically from the Middle East to China via India. In this part of the world, Indian hemp has been used since 1000 BC for a wide range of functions: as an analgesic (against headache, dental ..), anticonvulsant (against epilepsy, tetanus), tranquilizer (Anti-anxiety, hysteria …), anti-inflammatory (rheumatism ..), antispasmodic (colic, diarrhea), antibiotic, antiparasitic, stimulating appetite …
Used as an extract or dye, cannabis for therapeutic use appeared in Europe in the 19th century, mainly as sedative, analgesic, anti-emetic (vomiting) and anticonvulsant. But it was really only at the end of the 20th century, after the period of prohibition, that its medicinal qualities were studied scientifically and rigorously. In 1992, interest in this substance rebounded with the discovery by Prof. Raphael Mechoulam of a cannabis analogue made by the body itself, anandamide. According to this professor at the University of Jerusalem, “the endocannabinoid system plays a role in practically all the physiological systems that have been observed.” This will help guide research into the therapeutic uses of hemp.
Mode of action of cannabinoids
Endocannabinoids are substances produced naturally by the human body in very small quantities. Synthesized on demand, they interact with two types of receptors: the cannabinoid receptor 1 (CB1), which plays an essential role in the activation of neurons in our central nervous system (brain and spinal cord), and cannabinoid receptor 2. Being almost exclusively on the cells of our immune system, including the spleen. CB1 and CB2 are involved in many physiological processes such as, for example, cerebral maturation or bone mass.
Like the endocannabinoids, THC – or delta-9-tetrahydrocannabinol, the main active compound of cannabis – has a high affinity for these two types of receptors, which explains its psychotropic action but also its therapeutic potential.
Like THC, other plant cannabinoids present in cannabis can claim to have similar virtues. Among the 60 known compounds, cannabinol (CBN) and cannabidiol (CBD) are the most widespread and studied, the second – not psychoactive – is of particular interest to researchers for its remarkable anti-inflammatory properties associated with neuroprotective actions and an effect Antiarthritis in mice. In Israel, which has the highest rate of medical marijuana users in the world (normal being a pariah, land and resources stealing state, I guess people do not sleep well at night), an association would have developed and grow a new cannabis strain with an increased CBD content, THC was reduced.
Synthesizing cannabinoid substances with no psychotropic effects but proven therapeutic efficacy is one of the challenges of current research.